English - Español


October 13-16, 2016
Radisson Hotel
Montevideo, Uruguay

Opening Plenary Lecture
History of Mutagenesis in Latino-America
Catarina S. Takahashi (Brazil)
Plenary Lectures
1.  DNA damage responses: insights and applications.
Philip Hanawalt (USA)
2.  Cockayne Syndrome and mitochondrial dysfunctions: Toward a cure for progeroid patients?
Alain Sarasin (France)
3.  Role of genetic-environmental interactions in human health.
Patricia Ostrosky (Mexico)
4.  Cooking with Fire: The Mutagenicity - and PAH-Emission Factors for Solid-Fuel Cookstoves.
David DeMarini (USA)
5.  Effect directed analysis: linking cause and effect in complex mixtures.
Gisela Umbuzeiro (Brazil)
6.  Cancer in LatinAmerica.
Enrique Barrios (Uruguay)
Parallel Symposia
Symposium N° 1
Agrochemicals in the Region: A Multidisciplinary Overview
Coordinator: Marta A. Carballo (Argentina)
1.  Chlorpyrifos is an endocrine disrupter in mammary gland and interferes with cell growth regulation.
Claudia Cocca (Argentina)
2. Oxidative DNA damage induced by agrochemicals: native species and human biomonitoring studies.
María Fernanda Simoniello (Argentina)
3. Genotoxic effect resulting from occupational exposure to pesticides in the province of Jujuy.
Julio De Luca (Argentina)
Symposium N° 2
Arsenic: toxicity and influence on human health
Coordinator: María E Gonsebatt (Mexico)
1.  Metabolism and elimination of arsenic and genotoxic damage in Bolivian women exposed to contaminated water consumption.
Noemí Tirado (Bolivia)
2.  Gestational exposure to Arsenic: neurotoxic effects.
María E. Gonsebatt (Mexico)
3.  Diabetes induced by Arsenic.
Ana María Salazar (Mexico)
Symposium N° 3
What happens in the waters?
Coordinator: Deborah Roubicek (Brazil)
1.  Integrating tools for the toxicity and genotoxicity assessment of effluent samples.
Deborah Roubicek (Brazil)
2.  Progressive increase in disinfection by-products and mutagenicity from source to tap to swimming pool and spa water:  impact of human use.
David DeMarini (USA)
3.  Genotoxicity assessment of environmental samples containing disperse dyes and aromatic amines.
Francine Vacchi (Brazil)
Symposium N° 4
Mechanisms of repair protecting cells from DNA damage
Coordinator: Carlos F. M. Menck (Brazil)
1.  Replication DNA damage in human cells.
Carlos F. M. Menck (Brazil)
2.  Lack of XPC leads to a shift between respiratory complexes I and II but sensitizes cells to mitochondrial stress.
Nadja Souza-Pinto (Brazil)
3.  Nucleotide excision repair and photosensitive human diseases.
Graciela Spivak (USA)
4.  DNA repair in Fanconi Anemia.
Sara Frias (México)
5. Nucleotide excision repair in Trypanosoma cruzi: the major role of transcription coupled repair.
Carlos Renato Machado (Brazil)
Symposium N° 5
Nutrigenomics and Micronutrients
Coordinator: Lucia Regina Ribeiro (Brazil)
1.  Introduction.
Lucia Regina Ribeiro (Brazil)
2. The role of vitamin D on adipogenesis: new insights in human preadipocytes proliferation
Ingrid Felicidade (Brazil)
3.  Vitamin D supplementation of patients with type 2 diabetes mellitus.
Vanessa Moraes de Andrade (Brazil)
4.  Folate deficiency as an associated factor to malnutrition in mothers and children under two years in two Bolivian populations.
Ximena Aguilar Mercado (Bolivia)
Symposium N° 6
Current advances in the understanding the cellular response to genotoxic stress
Coordinator: Vanesa Gottifredi (Argentina)
1.  Development of a model for silencing of XPF and ERCC1 genes to study tumor resistance to chemotherapeutic agents.
Alessandra Pelegrini (Brazil)
2.  The tumor suppression function of p21CDKN1a exceeds and precedes cyclin kinase inactivation.
Vanesa Gottifredi (Argentina)
3.  Major roles of cyclobutane primidine dimers, nucleotide excision repair and ATR in the alternative splicing response to UV irradiation.
Manuel Muñoz (Argentina)
4.  Mechanisms of tumor agresiveness activated by mutant p53.
Javier Girardini (Argentina)
Symposium N° 7
Mechanisms and Topology of DNA Damage
Coordinators: Alejandro Bolzán, Gustavo A. Folle (Argentina, Uruguay)
1.  Introduction.
Gustavo Folle (Uruguay)
2.  Short- and Long-Term Effects of Streptozotocin on Mammalian Telomeres.
Alejandro Bolzán (Argentina)
3.  Preferential localization of gH2AX foci in euchromatin of retina rod cells after DNA damage induction.
Gustavo Folle (Uruguay)
4.  Bleomycin-induced gH2AX foci map preferentially to replicating domains in CHO9 interphase nuclei.
Ana Laura Reyes (Uruguay)
5.  gH2AX signals on CHO9 metaphase chromosomes.
María Vittoria Di Tomaso (Uruguay)
Symposium N° 8
Mechanisms of carcinogenicity and consequences of cancer therapy
Coordinator: Daisy Salvadori (Brazil)
1.  The use of experimental models for investigating oral carcinogenesis: pathogenesis, diagnosis and prevention.
Daniel Araki Ribeiro (Brazil)
2.  Inhibition of bladder cancer cell proliferation by natural products can be dependent on the TP53 status.
Glenda Nicioli da Silva (Brazil)
3.  Mechanisms of cardiotoxicity induced by the antineoplastic doxorrubicin.
Leonardo da Cunha Menezes Souza (Brazil)
Symposium N° 9
Nature as source of Protection and Antimutagenesis
Coordinator: Javier Espinosa (Mexico)
1.  Quimioprevention with flavonoids.
Javier Espinosa (México)
3.  Rorippa nasturtium: Antigenotoxic effect and modulation of oxidative biomarkers.
Marcela M. López Nigro (Argentina)
Symposium N° 10
Current Molecular Targeting Strategies for Tumor Resistance
Coordinator: Elza T. Sakamoto-Hojo (Brazil)
1.  DNA repair inhibition as therapeutic strategy in glioblastoma.
Elza T. Sakamoto-Hojo (Brazil)
2.  Strategies in breast cancer therapy to overcome the heterogeneity of tumor cells.
Gloria Calaf (Chile)
3.  E2F inhibition as molecular targets to sensitizing glioblastoma cells to radiation.
Paulo Roberto D. V. Godoy (Brazil)
4.  Mechanism based combination therapy in cancer: Telomerase and DNA repair inhibition.
M. Prakash Hande (Singapore)
5.  Impact of mobile phone specific electromagnetic radiofrequencies (EM-RF) on DNA stability in human glioblastoma cells.
Siegfried Knasmüller (Austria)
6.  Development of screening platforms for the identification of synthetic lethality inducers in homologous-recombination-deficient cancer cells.
Gastón Soria (Argentina)
Symposium N° 11
Environmental pollutants - Genotoxic and Cytotoxic Studies in Different Biotic Matrices
Coordinator: Marcelo L. Larramendy (Argentina)
1.  Genotoxicity induced by herbicides in non-conventional vertebrate species exposed under laboratory conditions.
Sonia Soloneski (Argentina)
2.  Genotoxicity and morphological effects of environmental contaminants on internal pigmented cells in Anurans.
Classius Oliveira and Lilian Franco-Belussi (Brazil)
3.  New approach to the study of pesticides and their mechanisms of damage in native reptile species.
Gisela Poletta (Argentina)
4.  Genotoxicity induced by occupational exposition to pesticides.
Juliana da Silva (Brazil)
5. Genetic damage by exposure to contaminants in municipal waste recycler women.
Deidamia Franco (Paraguay)
Symposium N° 12
Cellular response to antiproliferative agents with therapeutic potential
Coordinator: Mário Sérgio Mantovani (Brazil)

1.  Evaluation of the cellular response of primate species Cebus apella by treatment with nanoemulsion LDE associated with chemotherapy.
Rommel Mario Rodriguez Burbano (Brazil)

2.  Potential effects of Solanum lycocarpum and its isolated compounds in cancer therapy.
Denise Crispim Tavares (Brazil)

3.  Cytotoxic, genotoxic and apoptotic effect of plant alkaloid sanguinarine in vitro.
Veronica Elisa Pimenta Vicentini (Brazil)

4.  Selective antiproliferative activity of salinomycin in human breast cells.
Mário Sérgio Mantovani (Brazil)

5.  The phytochemical chlorophyllin alters cellular response to chemotherapeutic agents in vitro.
Gláucia Fernanda Rocha D’Epiro (Brazil)
Symposium N° 13
Oxidative stress response in Neglected Tropical Diseases
Coordinator: Carlos Renato Machado (Brazil)
1.  Antioxidant enzymes of Trypanosoma cruzi: virulence-key factors in the establishment of infection.
Carlos Robello (Uruguay)
2.  BER Pathway DNA repair in Trypanosoma cruzi in response to oxidative stress.
Gonzalo Cabrera (Chile)
3.  How does Trypanosoma cruzi deal with 8-oxoguanine.
Carlos Renato Machado (Brazil)
4.  DNA damage and gene expression profiles related to oxidative stress in controlled and poorly controlled Type-2 Diabetes Mellitus patients.
Danilo Jordão Xavier (Brazil)

Symposium N° 14
Natural products, nutrition and diet: latest news
Coordinator: Marta A. Carballo (Argentina)
1.  Anticarcinogenic activity of medicinal plants used in La Paz - Bolivia.
     Gloria Rodrigo (Bolivia)
2.  Infusion of Yerba Mate: Studies on anti-mutagenic and anti-inflammatory effects. Nelson Bracesco (Uruguay)
3.  Byrsonima verbascifolia, a chemotherapeutic agent trigger non apoptotic cell death.
     Ana Flavia Specian (Brazil)
4.  Phytometabolites isolated from equatorian plants: cytostatic and genotoxic activity.
Natalia Bailón-Moscoso (Ecuador)

Symposium N° 15
Use of biological dosimetry in radiological accidents and radioprotection
Coordinator: Elza T. Sakamoto-Hojo (Brazil)
1.  Radiation dosimetry - Lessons from Goiania accident in Brazil.
Elza T. Sakamoto-Hojo (Brazil)
2.  DNA damage response to mixed beams of high and low LET radiation.
Andrzej Wojcik (Sweden)
3.  A post-genomic integrated approach to analysing biological signatures of radiation exposure: Multiparametric approach.
M. Prakash Hande (Singapore)
4.  Mechanism underlying individual radiosensitivity of breast and head and neck cancer patients.
Siamak Haghdoost (Sweden)

Symposium N° 16
Searching alternative therapeutic approaches for Human Papillomavirus-associated tumors
Coordinator: Enrique Boccardo (Brazil)
1.  Biomarkers of genome instability in cervical cancer.
Lara Termini (Brazil)
2.  HPV mediated genome instability: the road to cancer...the road to the cure?
Enrique Boccardo (Brazil)
3.  Analysis of the impact of E6/E7 proteins of different molecular variants of HPV-16 upon MAPK signaling pathways .
Jimena Hochmann (Uruguay)
4.  Functional interaction between human papillomavirus and tobacco smoke in head and neck cancer.
Francisco Aguayo (Chile)
Symposium N° 17
Toxicogenetics and susceptibility gene polymorphisms
Coordinators: Ilce Cólus and Kátia Kvitko (Brazil)
1.  Immunosuppression, genetic polymorphisms, genotoxicity and graft rejection in kidney transplant patients.
Ilce Cólus (Brazil)
2.  Genetic susceptibility and response to occupational exposure.
Kátia Kvitko (Brazil)
3.  Polymorphisms of genes related to metabolism of lead (Pb) are associated with the metal body burden and biomarkers of oxidative stress.
Gustavo Rafael Mazzaron Barcelos (Brazil)
4.  Promoter methylation is related to micronuclei frequency in urothelial cells from individuals exposed to organic solvents.
Luz Stella Hoyos (Colombia)
Symposium N° 18
Biomedical approaches to cannabis therapy
Coordinators: Atilio Falconi, Carlos García and Búrix Mechoso (Uruguay)
1.  Introduction
Augusto Vitale (Uruguay)
2.  Interdisciplinary Center of Studies on Cannabis - UdelaR.
Búrix Mechoso (Uruguay)
3.  Genotyping studies on Cannabis varieties present in Uruguay.
Rosina Fossati (Uruguay)
4.  Phytochemical basis for the potential therapeutic use of Cannabis.
Santiago Fernández García (Uruguay)
5.  Effect of acute administration of Cannabis vaporized on sleep-wake cycle.
Alejandra Mondino (Uruguay)
Symposium N° 19
Environmental endogenous and exogenous stressors and genetic damage
Coordinator: M. Prakash Hande (Singapore)
1.  The effect of life style on the level of oxidative stress.
Siamak Hagdoost (Sweden)
2.  Endogenous DNA damage and genomic instability.
Deborah Keszenman (Uruguay)
3.  The textile dye Disperse Red 1 induces apoptosis-related genes in mice - elucidating its mode of action.
Fábio Henrique Fernandes (Brazil)
4.  In utero exposure to hyperglicemic environment can impair placenta and offspring.
João Paulo de Castro Marcondes (Brazil)
5.  Telomere dynamics and epigenetic status are altered in tobacco farmers.
Vivian Francilia Silva Kahl (Brazil)
Symposium N° 20
Micronutrients and its relationship with mutagenic and anti-mutagenic processes
Coordinator: Analía Seoane (Argentina)
1.  Cytomolecular analysis of radiomodulator potential of natural compounds.
Alba Güerci (Argentina)
2.  Nutrigenomics: relationship among nutrition, genomics and child growth.
Gisel Padula (Argentina)
3.  Folic acid enhances the apoptotic and genotoxic activity of carboplatin in a human cell line in vitro.
Analía Seoane (Argentina)
Symposium N° 21
Mate consumption and health
Coordinator: Nelson Bracesco (Uruguay)
1.  Protection against ionizing radiation by Ilex paraguariensis infusion and its polyphenolic component rutin in cell populations of Saccharomyces cerevisiae.
Lourdes Blanc (Uruguay)
2.  Yerba Mate: contribution, risks and benefits associated with its consumption.
Caterina Rufo (Uruguay)
3.  Effects of Mate consumption on the risk of breast cancer: the epidemiologic evidence.
Alvaro L. Ronco (Uruguay)
4.  Natural antioxidants and cancer: myths and realities.
Guillermo Schinella (Argentina)
Congreso Internacional Asociación Latinoamericana Mutagénesis, Carcinogénesis y Teratogénesis Ambiental - ALAMCTA - Montevideo, Uruguay.